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Students across eighty school districts are playing with skulls, fossils, and teeth while learning about math and science through the Biology in a Box program. The program—the brainchild of Susan Riechert, professor of ecology and evolutional biology and a collaboration with NIMBioS— consists of boxes which house scientific materials such as preserved specimens, instruments, audio and visual clips, etc., with corresponding exercises that integrates both science and mathematics through all grade levels. It has been successful in attracting students’ interest in science, technology, engineering and mathematics (STEM) disciplines by incorporating a hands-on, inquiry-based approach to teach the wonders of the living world, as well as introducing the scientific methods and math skills used to understand that world.